RECENT RESEARCH ON THE GROWTH PLATE: Advances in fibroblast growth factor signaling in growth plate development and disorders
نویسندگان
چکیده
منابع مشابه
Fibroblast growth factor expression in the postnatal growth plate.
Fibroblast growth factor (FGF) signaling is essential for endochondral bone formation. Mutations cause skeletal dysplasias including achondroplasia, the most common human skeletal dysplasia. Most previous work in this area has focused on embryonic chondrogenesis. To explore the role of FGF signaling in the postnatal growth plate, we quantitated expression of FGFs and FGF receptors (FGFRs) and e...
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Differentiation is the cellular process that regulates development of long bones and joint surface cartilage of synovial cavities. Growth plate cartilage development is commonly referred to as endochondral ossification which is the end stage of long bone development. Endochondral ossification proceeds as a continuum of chondrocyte proliferation cycles followed by non-proliferative phases couple...
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The growth plate is a highly organized cartilage structure with a complex cellular biology. Studies have been limited by the relative lack of relevant experimental models. Thanks to new technologies, e.g. targeted deletions of genes, knowledge is rapidly expanding. The first paper selected representing the mechanism of the year describes how estradiol can rescue skeletal growth during GH resist...
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Fibroblast growth factor receptor 3 (FGFR3) is a key regulator of skeletal growth and activating mutations in Fgfr3 cause achondroplasia, the most common genetic form of dwarfism in humans. Little is known about the mechanism by which FGFR3 inhibits bone growth and how FGFR3 signaling interacts with other signaling pathways that regulate endochondral ossification. To understand these mechanisms...
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ژورنال
عنوان ژورنال: Journal of Molecular Endocrinology
سال: 2014
ISSN: 0952-5041,1479-6813
DOI: 10.1530/jme-14-0012